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We have developed a novel, highly efficient  treatment of severe hetero- and homozygous familiar hypercholesterolemic patients. Low Density Lipoprotein (LDL) is eliminated by ex vivo immunoabsorption. The treatment is named Low Density Lipoprotein (LDL) apheresis. The method is being applied in several clinical centres around the world. LDL-apheresis paved the way for further applications in immunoadsorption apheresis in medicine.